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In a 12-month study, Second Nature members on tirzepatide lost an average of 22.1% of their body weight, with 95% achieving at least 10% weight loss 5

GLP-1 Weight Loss Without Exercise: What to Expect GLP-1 receptor agonists such as semaglutide (Wegovy) and liraglutide (Saxenda) can produce clinically significant weight loss without structured exercise, though outcomes vary between individuals